abstract：:Renal or hepatic impairment, often encountered in patients with type 2 diabetes, influences the pharmacokinetics and bioavailability of antihyperglycemic agents. An emerging concern is whether pharmacotherapy with incretin-based agents, the most recent drug classes to be introduced for type 2 diabetes, can be safely u...

journal_title：Endocrine

authors： Giorda CB,Nada E,Tartaglino B

更新日期：2014-08-01 00:00:00

abstract：:Progesterone is a steroid which regulates neural function, thereby modulating neurotransmission, cell survival, and behavior. Previous studies by our group have shown that chronic administration of low doses of progesterone in diestrus II female rats has an antidepressant-like effect in the forced swimming test (FST)....

journal_title：Endocrine

authors： Arbo BD,Andrade S,Osterkamp G,Gomez R,Ribeiro MF

更新日期：2014-08-01 00:00:00

abstract：:Inflammation is associated with several tumor development and progression. However, these associations are not clear in well-differentiated thyroid carcinomas. We assessed whether NLR is a useful prognostic marker in patients with papillary thyroid carcinomas (PTC). The medical records of all patients who underwent th...

journal_title：Endocrine

authors： Kim JY,Park T,Jeong SH,Jeong CY,Ju YT,Lee YJ,Hong SC,Ha WS,Choi SK,Jung EJ

更新日期：2014-08-01 00:00:00

abstract：:A great number of prospective studies have investigated the relationship between leisure time physical activity (LTPA) and metabolic syndrome (MetS) risk. However, the results have been inconsistent. The aim of this study was to clarify the relationship between LTPA and MetS risk. Literature databases were searched in...

journal_title：Endocrine

authors： He D,Xi B,Xue J,Huai P,Zhang M,Li J

更新日期：2014-06-01 00:00:00

abstract：:To evaluate whether continuous subcutaneous insulin infusion (CSII) may have any advantage over multiple daily injections (MDI) on glycemic control and treatment satisfaction in young patients with Type 1 diabetes in transition to an adult diabetes center. The study population consisted of 125 patients on MDI; 38 out ...

journal_title：Endocrine

authors： Maiorino MI,Bellastella G,Petrizzo M,Improta MR,Brancario C,Castaldo F,Olita L,Giugliano D

更新日期：2014-06-01 00:00:00

abstract：:To report on the incidence and use of kelp among patients with thyroid cancer. Data were collected using a web-based online anonymous survey under Institutional Review Board approval from Boston University. This report is based on 27 responses from subjects with thyroid cancer who use kelp. Demographic factors and com...

journal_title：Endocrine

authors： Rosen JE,Gardiner P,Saper RB,Pearce EN,Hammer K,Gupta-Lawrence RL,Lee SL

更新日期：2014-05-01 00:00:00

abstract：:Skeletal muscle atrophy is associated with type-1 diabetes. Skeletal muscle is the source of pro- and anti-inflammatory cytokines that can mediate muscle hypertrophy and atrophy, while resistance exercise can modulate both muscle mass and muscle cytokine expression. This study determined the effects of a 5-week resist...

journal_title：Endocrine

authors： Molanouri Shamsi M,Hassan ZH,Gharakhanlou R,Quinn LS,Azadmanesh K,Baghersad L,Isanejad A,Mahdavi M

更新日期：2014-05-01 00:00:00

abstract：:Metabolic syndrome has become a major public health problem worldwide and represents a common clinical condition in countries with a high incidence of obesity and western dietary patterns. Metabolic syndrome associates with common cancers at many sites, including liver, colorectal, and bladder cancers in men, and endo...

journal_title：Endocrine

authors： Esposito K,Capuano A,Giugliano D

更新日期：2014-04-01 00:00:00

abstract：:The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This study provides a comprehensive evaluation of the relationship between the genetic risks of CTLA-4 +49 A/G polymorphism...

journal_title：Endocrine

authors： Qiu H,Tang W,Yin P,Cheng F,Wang L

更新日期：2014-03-01 00:00:00

abstract：:To determine whether the administration of small amounts of glucose through an oral spray device (GSD) facilitates weight loss in overweight/obese subjects involved in a lifestyle modification programme. We randomly assigned 56 overweight/obese subjects to either the treatment group (n = 32) or the control group (n = ...

journal_title：Endocrine

authors： Khazrai YM,Maddaloni E,Altomare M,Cacciapaglia F,Pozzilli P

更新日期：2014-03-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common health problem, and associated with obesity, metabolic syndrome (MetS), and diabetes. Growing evidence shows that 25-hydroxyvitamin-D3 (25-OH-D) insufficiency and high parathyroid hormone (PTH) levels may be correlated to glucose intolerance, MetS, obesity, and cardi...

journal_title：Endocrine

authors： Erden ES,Genc S,Motor S,Ustun I,Ulutas KT,Bilgic HK,Oktar S,Sungur S,Erem C,Gokce C

更新日期：2014-03-01 00:00:00

abstract：:Regular endurance exercise promotes metabolic and oxidative changes in skeletal muscle. Overexpression of interleukin-15 (IL-15) in mice exerts similar metabolic changes in muscle as seen with endurance exercise. Muscular IL-15 production has been shown to increase in mice after weeks of regular endurance running. Wit...

journal_title：Endocrine

authors： Rinnov A,Yfanti C,Nielsen S,Akerström TC,Peijs L,Zankari A,Fischer CP,Pedersen BK

更新日期：2014-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) have been identified to play important functions during osteoblast proliferation, differentiation, and apoptosis. The miR-17~92 cluster is highly conserved in all vertebrates. Loss-of-function of the miR-17-92 cluster results in smaller embryos and immediate postnatal death of all animals. Germline ...

journal_title：Endocrine

authors： Zhou M,Ma J,Chen S,Chen X,Yu X

更新日期：2014-03-01 00:00:00

abstract：:Medullary thyroid carcinoma (MTC) is a rare tumour which frequently occurs in the context of the multiple endocrine neoplasia syndromes, where it coexists with other usually benign tumours. The clinical picture varies and distant metastases are frequently present at diagnosis. Calcitonin levels are elevated in the pre...

journal_title：Endocrine

authors： Alevizaki M,Kyratzoglou E,Bamias A,Tzanela M,Dimopoulos MA,Saltiki K

更新日期：2013-12-01 00:00:00

abstract：:Radioiodide ((131)I) is routinely used for the treatment of toxic adenoma, Graves' disease, and for ablation of thyroid remnant after thyroidectomy in patients with thyroid cancer. The toxic effects of ionizing radiations on living cells can be mediated by a necrotic and/or apoptotic process. The involvement of apopto...

journal_title：Endocrine

authors： Russo E,Guerra A,Marotta V,Faggiano A,Colao A,Del Vecchio S,Tonacchera M,Vitale M

更新日期：2013-12-01 00:00:00

abstract：:Autoimmune thyroid diseases (AITDs) (Hashimoto thyroiditis and Graves' disease) are complex polygenic disorders with multiple genes thought to contribute to the risk of disease. The contribution of these genes differs by different populations. The PTPN22 gene is reported to be associated with multiple autoimmune disea...

journal_title：Endocrine

authors： Alkhateeb A,Marzouka NA,Tashtoush R

更新日期：2013-12-01 00:00:00

abstract：:Persistent hyperglycemia is associated with chronic oxidative stress which contributes to the development and progression of diabetes-associated complications. The sensitivity of pancreatic β-cells to oxidative stress has been attributed to their low content of antioxidants compared with other tissues. Bioactive compo...

journal_title：Endocrine

authors： Prasath GS,Sundaram CS,Subramanian SP

更新日期：2013-10-01 00:00:00

abstract：:This study investigated the impact of incretin on early-phase insulin secretion and glucose excursion. The normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM) groups included 16, 8, and 19 subjects, respectively. Subjects underwent continuous glucose monitoring for 3 d...

journal_title：Endocrine

authors： Shen J,Chen Z,Chen C,Zhu X,Han Y

更新日期：2013-10-01 00:00:00

abstract：:Autoimmune thyroiditis (AIT) is a systemic disease. It is well-known that overt thyroid dysfunction is a cardiovascular risk factor. However, the influence of euthyroid status is unclear. The aim of this study was to evaluate the metabolic parameters and carotid intima-media thickness (CIMT) in euthyroid premenopausal...

journal_title：Endocrine

authors： Topaloglu O,Gokay F,Kucukler K,Burnik FS,Mete T,Yavuz HC,Berker D,Guler S

更新日期：2013-08-01 00:00:00

abstract：:Intracranial tumors of different histologic types infrequently affect patients with pituitary adenomas and no history of head irradiation. The association with craniopharyngioma is extremely rare. Aims of this paper are: (1) to provide a critical literature review of typical features of pituitary adenoma presenting in...

journal_title：Endocrine

authors： Guaraldi F,Prencipe N,di Giacomo V,Scanarini M,Gasco V,Gardiman MP,Berton AM,Ghigo E,Grottoli S

更新日期：2013-08-01 00:00:00

abstract：:Growth hormone (GH) and prolactin share similarities in structure and function. We have previously shown that women with congenital isolated GH deficiency (IGHD) caused by a homozygous mutation in the GHRH receptor gene (GHRHR) (MUT/MUT) have a short reproductive life, with anticipated climacteric. At climacteric, the...

journal_title：Endocrine

authors： Menezes M,Salvatori R,Melo LD,Rocha ÍE,Oliveira CR,Pereira RM,Souza AH,Valença EH,Melo EV,Campos VC,Costa FO,Aguiar-Oliveira MH

更新日期：2013-08-01 00:00:00

abstract：:Interleukin 15 (IL-15) has recently been proposed as a myokine involved in regulating lipid metabolism. We investigated the effect of exercise training on IL-15 content in skeletal muscle and expression of IL-15 receptor (IL-15R) in adipose tissue of obese rats. After 12 weeks of a high-fat diet, obese rats underwent ...

journal_title：Endocrine

authors： Yang H,Chang J,Chen W,Zhao L,Qu B,Tang C,Qi Y,Zhang J

更新日期：2013-06-01 00:00:00

abstract：:The handgrip strength is considered an excellent predictor of morbidity and mortality for acute and long term outcomes. In fact, several studies showed that the reduced handgrip strength is correlated to all-cause mortality in both middle aged and elderly subjects. Nevertheless, defined reference values of handgrip st...

journal_title：Endocrine

authors： Montalcini T,Migliaccio V,Yvelise F,Rotundo S,Mazza E,Liberato A,Pujia A

更新日期：2013-04-01 00:00:00

abstract：:AdipoR1 is one of the adiponectin receptors which are important for adiponectin signaling. Because adiponectin is a candidate gene for common obesity, it is also hypothesized that variations in AdipoR1 may be involved in the development of complex obesity. Therefore, we designed an association study for the AdipoR1 ge...

journal_title：Endocrine

authors： Beckers S,de Freitas F,Zegers D,Mertens IL,Verrijken A,Van Camp JK,Van Gaal LF,Van Hul W

更新日期：2013-02-01 00:00:00

abstract：:The diagnostic performance of positron emission tomography using ¹¹C-methionine (MET-PET) in detecting parathyroid adenoma has been investigated by several studies with conflicting results. Aim of our study is to meta-analyze published data about this topic. A comprehensive computer literature search of studies publis...

journal_title：Endocrine

authors： Caldarella C,Treglia G,Isgrò MA,Giordano A

更新日期：2013-02-01 00:00:00

abstract：:RF amide peptide family with distinctive terminal -Arg-Phe-NH(2) signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebrates including influencing pituitary hormone secretion. More recently, two members of this fa...

journal_title：Endocrine

authors： Qaiser F,Wahab F,Wiqar MA,Hashim R,Leprince J,Vaudry H,Tena-Sempere M,Shahab M

更新日期：2012-12-01 00:00:00

abstract：:Aberrant accumulation of β-catenin plays an important role in a variety of human neoplasms. This can be caused by stabilizing mutation of β-catenin (CTNNB1, exon 3) or by mutation or deregulated expression of other components of the WNT/β-catenin signaling pathway. Accumulation of non-phosphorylated active β-catenin h...

journal_title：Endocrine

authors： Starker LF,Fonseca AL,Akerström G,Björklund P,Westin G,Carling T

更新日期：2012-12-01 00:00:00

abstract：:For analyzing the changes in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence of fever associated with the it. The study included 11 subj...

journal_title：Endocrine

authors： Aydin S,Guven T,Sahin İ,Aksoy A,Kendir Y,İlhan MN,Citil C,Catak Z,Ustun C

更新日期：2012-10-01 00:00:00

abstract：:We wanted to evaluate the cutaneous synthesis of 25OHD and cholecalciferol after one whole-body exposure to ultraviolet radiation type B (UVB) in a randomized setup. Healthy volunteers were randomized to one whole-body exposure in a commercial tanning bed with UVB emission (UVB/UVA ratio 1.8-2.0%) or an identical plac...

journal_title：Endocrine

authors： Langdahl JH,Schierbeck LL,Bang UC,Jensen JE

更新日期：2012-10-01 00:00:00

abstract：UNLABELLED:Gallium-68 somatostatin receptor (SMSR) positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are valuable diagnostic tools for patients with neuroendocrine tumours (NETs). To date, a meta-analysis about the diagnostic accuracy of these imaging methods is lacking. A...

journal_title：Endocrine

authors： Treglia G,Castaldi P,Rindi G,Giordano A,Rufini V

更新日期：2012-08-01 00:00:00

abstract：:Inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) is considered as a major predictor of cardiovascular events. Apolipoprotein B (ApoB) directly reflects the number of plasma atherogenic lipoproteins, and may play a major role in vascular inflammation. We aimed to assess whether an association between ...

journal_title：Endocrine

authors： Xu W,Li R,Zhang S,Gong L,Wang Z,Ren W,Xia C,Li Q

更新日期：2012-08-01 00:00:00

abstract：:Hypertensive heart disease, here defined by the presence of pathologic left ventricular hypertrophy in the absence of a cause other than arterial hypertension, is characterized by complex changes in myocardial structure including enhanced cardiomyocyte growth and non-cardiomyocyte alterations that induce the remodelin...

journal_title：Endocrine

authors： González A,López B,Ravassa S,Beaumont J,Zudaire A,Gallego I,Brugnolaro C,Díez J

更新日期：2012-08-01 00:00:00

abstract：:RECK (reversion-inducing cysteine-rich protein with Kazal motifs) is a membrane-anchored glycoprotein which regulates MMP2 and MMP9 activity and has been proposed to play a role in embryo implantation while misexpression of RECK has been associated with a variety of carcinomas. Unfortunately, understanding on the ster...

journal_title：Endocrine

authors： Zhang X,Healy C,Nothnick WB

更新日期：2012-08-01 00:00:00

abstract：:This study estimates diagnostic performance of late-night salivary cortisol (LNSC) as measured by automated electrochemiluminescence immunoassay (ECLIA), evaluates the clinical implication of two consecutive LNSC measurements, and compares its accuracy with enzyme-linked immunosorbent assay (ELISA) and serum cortisol ...

journal_title：Endocrine

authors： Belaya ZE,Iljin AV,Melnichenko GA,Rozhinskaya LY,Dragunova NV,Dzeranova LK,Butrova SA,Troshina EA,Dedov II

更新日期：2012-06-01 00:00:00

abstract：:To investigate the adrenal effect of a phytosterol (PS) additive, 80 male Japanese quail were divided into four sub-groups and fed 0, 40, 400, and 4,000 ppm of PS, respectively, for 21 days. Subsequently, 50% of the birds from each dosage group were subjected to a 6-day adrenal function test, whereby they were injecte...

journal_title：Endocrine

authors： Liu F,Chen J,Shi F,Wang T,Watanabe G,Taya K

更新日期：2012-04-01 00:00:00

abstract：:Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are relatively rare and heterogenous malignancies. Recent advances in histopathological classification according to the anatomical site of origin, proliferation rate, and extend of the disease have created a valid and powerful tool for the prognostic stratificati...

journal_title：Endocrine

authors： Alexandraki KI,Kaltsas G

更新日期：2012-02-01 00:00:00

abstract：:This study was performed to ascertain whether a relationship exists between thyroid function and blood pressure in school-aged Chinese subjects without overt thyroid disease. A cross-sectional survey of 880 subjects (541 females and 339 males) aged 7-18 years in Bengbu, Anhui province was conducted. The investigation,...

journal_title：Endocrine

authors： Chen H,Xi Q,Zhang H,Song B,Liu X,Mao X,Li J,Shen H,Tang W,Zhang J,Wang Z,Duan Y,Liu C

更新日期：2012-02-01 00:00:00

abstract：:The process of homo- and/or heterodimerization of G-protein coupled receptors (GPCRs) and receptor tyrosine kinase (RTK) families are crucial for implicating the fundamental properties of receptor proteins including receptor expression, trafficking, and desensitization as well as signal transduction. The members of GP...

journal_title：Endocrine

authors： Kumar U

更新日期：2011-10-01 00:00:00

abstract：:Data on the antioxidant levels enzyme in patients with hyperthyroidism are limited and conflicting. Therefore, the objective of this study was to evaluate the oxidative status using an automated method in patients with hyperthyroidism. Thirty-six subjects with hyperthyroidism and 30 healthy controls were enrolled in t...

journal_title：Endocrine

authors： Aslan M,Cosar N,Celik H,Aksoy N,Dulger AC,Begenik H,Soyoral YU,Kucukoglu ME,Selek S

更新日期：2011-10-01 00:00:00

abstract：:Ghrelin is an endogenous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+ concentration ([Ca2+]i), which is determined by Ca2+ influx and release from intracellular Ca2+ storage sites. Ca2+ influx...

journal_title：Endocrine

authors： Han X,Zhu Y,Zhao Y,Chen C

更新日期：2011-10-01 00:00:00